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Literature summary for 3.4.21.68 extracted from

  • Medina, M.G.; Ledesma, M.D.; Dominguez, J.E.; Medina, M.; Zafra, D.; Alameda, F.; Dotti, C.G.; Navarro, P.
    Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation (2005), EMBO J., 24, 1706-1716.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Inhibitors

Inhibitors Comment Organism Structure
2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
 Mus musculus
2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?
plasminogen + H2O Rattus norvegicus
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P11214
-
-
Rattus norvegicus P19637
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain primary hippocampal neuron Mus musculus
-
brain primary hippocampal neuron Rattus norvegicus
-
Neuro-2a cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?
plasminogen + H2O
-
 Rattus norvegicus plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
Tissue plasminogen activator
-
 Rattus norvegicus
tPA
-
 Mus musculus
tPA
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000035
-
 2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
 Mus musculus
0.000035
-
 2,7-bis-(4-amidinobenzylidene)-cycloheptanone-(1)dihydrochloride
-
 Rattus norvegicus