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Literature summary for 3.4.21.68 extracted from
- Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function (1997), Curr. Opin. Struct. Biol., 7, 865-872.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of many components, crystallizing of full-length intact human t-PA have failed so far | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| serpin plasminogen activator inhibitor (PAI)-1 | primary physiological inhibitor | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | Homo sapiens | cleavage of the Arg561-Val562 bond of plasminogen, converting the zymogen into the active serine protease plasmin | plasmin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | single-chain t-PA, sct-PA can be converted to two-chain forrm, tct-PA, by activation cleavage at the arg275-Ile276 peptide bond | Homo sapiens | ? | - |
? | |
| plasminogen + H2O | cleavage of the Arg561-Val562 bond of plasminogen, converting the zymogen into the active serine protease plasmin | Homo sapiens | plasmin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue-type plasminogen activator | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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