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Literature summary for 3.4.21.68 extracted from
- Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator (1992), J. Biol. Chem., 267, 11693-11696.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Human plasminogen activator inhibitors | PAI-1; PAI-1 may occur in three interconvertible conformations: latent, inhibitor and substrate | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
Genentech | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | mutant form of t-PA in which the active site serine is replaced by alanine, from Genentech, San Francisco | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? |  |
| Plasminogen-activator-inhibitor 1 + H2O | PAI-1 may occur in three interconvertible conformations: latent, inhibitor and substrate | Homo sapiens | ? | - |
? | |
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