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Literature summary for 3.4.21.68 extracted from
- A substrate-like form of plasminogen-activator-inhibitor type 1. Conversions between different forms by sodium dodecyl sulphate (1992), Eur. J. Biochem., 209, 985-992.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Human plasminogen activator inhibitors | after treatment with 0.01% SDS, active PAI-1 is converted to an inactive form that does not form complexes with PA, after treatment with 0.1% SDS, PAI-1 loses its inhibitory activity and is cleaved as a substrate in the reactive centre; PAI-1 | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | Biopool AB, Umea, Sweden | Escherichia coli | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| plasminogen + H2O | - |
Escherichia coli | plasmin + ? | - |
? |  |
| Plasminogen-activator-inhibitor 1 + H2O | treatment with 0.1% SDS, PAI-1 loses its inhibitory activity and is cleaved as a substrate in the reactive centre | Escherichia coli | ? | - |
? | |
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