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Literature summary for 3.4.21.68 extracted from

  • Madison, E.L.; Coombs, G.S.; Corey, D.R.
    Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen (1995), J. Biol. Chem., 270, 7558-7562.
    View publication on PubMed
Search for more literature for 3.4.21.68

Activating Compound

Activating Compound Comment Organism Structure
Fibrin enhances activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000018
-
 plasminogen activated with fibrin Homo sapiens
0.0076
-
 plasminogen without fibrin Homo sapiens
3.6
-
 Lys-Lys-Ser-Pro-Gly-Arg-Val-Val-Gly-Gly-Ser-Val-Ala-His
-
 Homo sapiens
5.9
-
 Lys-Lys-Cys-Pro-Gly-Arg-Val-Val-Gly-Gly-Cys-Val-Ala-His
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 Genentech
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation Genentech, San Francisco Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Lys-Lys-Cys-Pro-Gly-Arg-Val-Val-Gly-Gly-Cys-Val-Ala-His + H2O
-
 Homo sapiens ?
-
 ?
Lys-Lys-Ser-Pro-Gly-Arg-Val-Val-Gly-Gly-Ser-Val-Ala-His + H2O
-
 Homo sapiens ?
-
 ?
additional information cleaves linear and cyclic peptides containing its normal target sequence from plasminogen Homo sapiens ?
-
 ?
plasminogen + H2O cleavage of Arg560-Val561 Homo sapiens plasmin + ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0012
-
 Lys-Lys-Ser-Pro-Gly-Arg-Val-Val-Gly-Gly-Ser-Val-Ala-His
-
 Homo sapiens
0.009
-
 Lys-Lys-Cys-Pro-Gly-Arg-Val-Val-Gly-Gly-Cys-Val-Ala-His
-
 Homo sapiens
0.2
-
 plasminogen without fibrin and activated with fibrin Homo sapiens