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Literature summary for 3.4.21.62 extracted from

  • Swenerton, R.K.; Knudsen, G.M.; Sajid, M.; Kelly, B.L.; McKerrow, J.H.
    Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology (2010), J. Biol. Chem., 285, 31120-31129.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani
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-
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Synonyms

Synonyms Comment Organism
subtilisin protease
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Leishmania donovani

General Information

General Information Comment Organism
malfunction gene knock-out results in reduced ability by the parasite to undergo promastigote to amastigote differentiation in vitro. SUB-deficient Leishmania display reduced virulence in infection models. SUB knock-out parasites show altered regulation of the terminal peroxidases of the trypanothione reductase system and the predominant tryparedoxin peroxidases are decreased in SUB-/- parasites. knock-out parasites show increased sensitivity to hydroperoxide. Data suggest that subtilisin is the maturase for tryparedoxin peroxidases and is necessary for full virulence Leishmania donovani