Cloned (Comment) | Organism |
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- |
Leishmania donovani |
Organism | UniProt | Comment | Textmining |
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Leishmania donovani | - |
- |
- |
Synonyms | Comment | Organism |
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subtilisin protease | - |
Leishmania donovani |
General Information | Comment | Organism |
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malfunction | gene knock-out results in reduced ability by the parasite to undergo promastigote to amastigote differentiation in vitro. SUB-deficient Leishmania display reduced virulence in infection models. SUB knock-out parasites show altered regulation of the terminal peroxidases of the trypanothione reductase system and the predominant tryparedoxin peroxidases are decreased in SUB-/- parasites. knock-out parasites show increased sensitivity to hydroperoxide. Data suggest that subtilisin is the maturase for tryparedoxin peroxidases and is necessary for full virulence | Leishmania donovani |