Literature summary for 3.4.21.61 extracted from

Jiang, H.; Wang, L.; Wang, F.; Pan, J.
Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-kappaB, signal transducer and activator of transcription 3 and activator of transcription 3 and extracellular signal regulated 1/2 pathways (2017), Mol. Med. Rep., 16, 8477-8484 .

Search for more literature for 3.4.21.61

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29122	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
rheumatoid arthritis disease specific fibroblast-like synoviocyte	-	Homo sapiens	-
synovial fibroblast	from knee joint	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PCSK6	-	Homo sapiens
proprotein convertase subtilisin/kexin type 6	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	PCSK6 can activate NF-kappaB, STAT3 and ERK1/2 signaling pathways in vitro to enhance cell proliferation, migration, invasion and inflammation in rheumatoid arthritis synovial fibroblast (RASF) cells. Recombinant enzyme rhPCSK6 promotes the production of pro-inflammatory factors in RASFs. Pro?inflammatory cytokines serve promixadnent roles in rheumatoid arthritis. RASFs can secrete interleukin (IL)-1alpha, IL-1beta, IL-6, IL-17, and TNF-alpha	Homo sapiens
physiological function	proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-kappaB, signal transducer and activator of transcription 3 and activator of transcription 3 and extracellular signal regulated 1/2 pathways. rhPCSK6 induces activation of the ERK1/2, STAT3 and NF-kappaB signaling pathways	Homo sapiens

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Release 2023.1 (January 2023)