Cloned (Comment) | Organism |
---|---|
expression in HEK293 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D374Y | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
S127R | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
low density lipoprotein receptor + H2O | PCSK9 binding to cell surface low density lipoprotein receptor cannot be described by a simple bimolecular reaction. Data suggest the presence of two populations of binding site | Homo sapiens | ? | - |
? |