Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lovastatin | suppresses endogenous synthesis of sterols, increases both the proteins and mRNAs for PCSK9. 10 mM can reverse the increase of PCSK9 expression by lovastatin | Homo sapiens | |
additional information | depletion of sterols induces PCSK9 in a time-dependent manner | Homo sapiens | |
additional information | PCSK9 protein and mRNA are increased by refeeding after fasting. Supplementation with 2% cholesterol in the diet prevents the increase in PCSK9 | Mus musculus | |
sodium mevalonate | suppresses endogenous synthesis of sterols, PCSK9 is further increased | Homo sapiens | |
sterol-regulatory element binding protein-1 | dramatically increases the promoter activity of PCSK9 | Homo sapiens | |
sterol-regulatory element binding protein-2 | dramatically increases the promoter activity of PCSK9 | Homo sapiens | |
sterol-regulatory element binding protein-2 | predominantly mediates sterol-dependent regulation of PCSK9 in vivo | Mus musculus |
Application | Comment | Organism |
---|---|---|
additional information | expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both SREBP-1 and SREBP-2 can transcriptionally activate PCSK9 via sterol-regulatory element in its proximal promoter region in vitro | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into vector pET-21a(+) | Homo sapiens |
ligated into vector pCR2.1-Topo and subcloned into vector pET-21a(+) | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PCSK9 protein and mRNA are decreased significantly by fasting | Mus musculus | |
sterol | completely blocks increase in PCSK9 mRNA by lovastatin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male C57B/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PCSK9 | - |
Mus musculus |
PCSK9 | - |
Homo sapiens |
proprotein convertase subtilisin/kexin type 9 | - |
Mus musculus |
proprotein convertase subtilisin/kexin type 9 | - |
Homo sapiens |