Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.61 extracted from

  • Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
    Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor (2006), J. Biol. Chem., 281, 11050-11057.
    View publication on PubMed
Search for more literature for 3.4.21.61

Application

Application Comment Organism
degradation PC1/3 is essential and sufficient for the production of the intestinal incretin hormone GIP Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
adenovirus construct expressing PC1/3 Mus musculus
GH4 cells co-transfected with preproGIP and PC1/3 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information PC1/3-deficient mice show severely impaired processing to GIP Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell expresses high levels of endogenous PC1/3 Mus musculus
-
intestine co-localization of GIP and PC1/3 Mus musculus
-
additional information alpha-TC1.9 cells do not express PC1/3 Mus musculus
-
additional information GH4 cell expresses low levels of PC1/3 Rattus norvegicus
-
pancreatic islet
-
 Mus musculus
-
pancreatic islet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proGIP + H2O
-
 Mus musculus GIP
-
 ?
proGIP + H2O
-
 Rattus norvegicus GIP
-
 ?

Synonyms

Synonyms Comment Organism
PC 1/3
-
 Mus musculus
PC 1/3
-
 Rattus norvegicus
prohormone convertase 1/3
-
 Mus musculus
prohormone convertase 1/3
-
 Rattus norvegicus