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Literature summary for 3.4.21.61 extracted from

  • Bessmertnaya, L.; Loiko, II; Goncharova, T.I.; Ivanov, N.V.; Rumsh, L.D.; Antonov, V.K.
    Specific cleavage of hybrid proteins by proteinase encoded by the KEX2 gene (1997), Biochemistry, 62, 850-857.
    View publication on PubMed
Search for more literature for 3.4.21.61

Inhibitors

Inhibitors Comment Organism Structure
DFP
-
 Saccharomyces cerevisiae
EDTA
-
 Saccharomyces cerevisiae
HgCl2
-
 Saccharomyces cerevisiae
human urine trypsin inhibitor most potent inhibitor Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Saccharomyces cerevisiae 5794
-
membrane membrane-bound Saccharomyces cerevisiae 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae transforming the precursors of biologically active agents into their functional forms, processing and conversion of prohormones ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 yeast, strain X-2180, haploid cells
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-Leu-Lys-Arg-p-nitroanilide + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
additional information hydrolyzes peptides and proteins with basic amino acid pairs which are cleaved at the C-ends of their peptide bonds, cleaves specifically large recombinant proteins, for example a protein consisting of a gamma-interferon fragment linked to HIV1-proteinase via a Lys-Arg-containing peptide Saccharomyces cerevisiae ?
-
 ?
additional information transforming the precursors of biologically active agents into their functional forms, processing and conversion of prohormones Saccharomyces cerevisiae ?
-
 ?
Proinsulin + H2O cleaves human proinsulin at the peptide bond between Arg32 and Glu33 Saccharomyces cerevisiae Insulin + ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
6 9
-
 Saccharomyces cerevisiae