Literature summary for 3.4.21.60 extracted from

Pomowski, A.; Ustok, F.I.; Huntington, J.A.
Homology model of human prothrombinase based on the crystal structure of Pseutarin C (2014), Biol. Chem., 395, 1233-1241.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure homology modelling using the crystal structure of Pseutarin C, structure analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	thrombin is generated from prothrombin through cleavage at two sites by the prothrombinase complex. Prothrombinase is composed of a protease, factor Xa, and a cofactor, factor Va, which interact on negatively charged phospholipid surfaces and cleave prothrombin into thrombin 300000times faster than factor Xa alone The enzyme is responsible for the balance between bleeding and thrombosis	Homo sapiens

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Release 2023.1 (January 2023)