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Literature summary for 3.4.21.6 extracted from

  • Kamata, K.; Kawamoto, H.; Honma, T.; Iwama, T.; Kim, S.H.
    Structural basis for chemical inhibition of human blood coagulation factor Xa (1998), Proc. Natl. Acad. Sci. USA, 95, 6630-6635.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
complex between the enzyme from which the residues 1-44 of the light chain have been removed and the inhibitor (2RS)-(3'-amidino-3-biphenyl)-5-(4-pyridylamino)pentanoic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2RS)-(3'-amidino-3-biphenyl)-5-(4-pyridylamino)pentanoic acid i.e. FX-2212, 50% inhibition by 272 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00742 enzyme from which the residues 1-44 of the light chain have been removed
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000272
-
 (2RS)-(3'-amidino-3-biphenyl)-5-(4-pyridylamino)pentanoic acid i.e. FX-2212 Homo sapiens