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Literature summary for 3.4.21.6 extracted from

  • Robinson, D.J.; Furie, B.; Furie, B.C.; Bing, D.H.
    Active site of bovine factor Xa. Characterization using substituted benzamidines as competitive inhibitors and affinity-labeling reagents (1980), J. Biol. Chem., 255, 2014-2021.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
diisopropylfluorophosphate
-
 Bos taurus
m-(o-(2-chloro-5-fluorosulfonylphenylureido)phenoxybutoxy)benzamidine
-
 Bos taurus
p-amidinophenylmethanesulfonyl fluoride
-
 Bos taurus
p-nitrophenylguanidinobenzoate
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0377
-
 Nalpha-benzyloxycarbonyl-L-Lys-p-nitrophenyl ester
-
 Bos taurus
0.0867
-
 benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide native enzyme Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification factor X is the zymogen Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide + H2O
-
 Bos taurus ?
-
 ?
benzoyl-Ile-Glu-(-H/OMe)-Gly-Arg-p-nitroanilide + H2O
-
 Bos taurus ?
-
 ?
Nalpha-benzyloxycarbonyl-L-Lys-4-nitrophenyl ester + H2O
-
 Bos taurus Nalpha-benzyloxycarbonyl-L-Lys + 4-nitrophenol
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.17
-
 Nalpha-benzyloxycarbonyl-L-Lys-p-nitrophenyl ester
-
 Bos taurus
145
-
 benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide native enzyme Bos taurus
146
-
 benzoyl-Ile-Glu-(-H/OMe)-Gly-Arg-p-nitroanilide native enzyme Bos taurus