Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(2-methylphenyl)benzamide | 16% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(3-methylphenyl)benzamide | 88% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(4-methylphenyl)benzamide | 94% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(4-methylpyridin-2-yl)benzamide | 56% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(4-phenoxyphenyl)benzamide | 22% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(5-methylpyridin-2-yl)benzamide | 73% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(6-methylpyridin-2-yl)benzamide | 9% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-(pyridin-2-yl)benzamide | 38% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-[4-(propan-2-yl)phenyl]benzamide | 23% inhibition at 0.00136 mM | Homo sapiens | |
2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}-N-[4-(trifluoromethoxy)phenyl]benzamide | 32% inhibition at 0.00136 mM | Homo sapiens | |
3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]-N-(5-methyl-2-pyridyl)benzamide | - |
Homo sapiens | |
3-hydroxy-4'-methoxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | - |
Homo sapiens | |
3-hydroxy-4'-methoxy-4-methyl-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | - |
Homo sapiens | |
3-hydroxy-4'-methyl-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | - |
Homo sapiens | |
3-hydroxy-N-(5-methoxy-2-pyridyl)-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | - |
Homo sapiens | |
3-[(4-methoxyphenyl)carbamoyl]-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]phenyl beta-D-glucopyranosiduronic acid | - |
Homo sapiens | |
4'-chloro-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | - |
Homo sapiens | |
5-chloro-3-hydroxy-4'-methoxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | - |
Homo sapiens | |
5-chloro-3-[(5-chloro-2-pyridyl)carbamoyl]-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]phenyl beta-D-glucopyranosiduronic acid | - |
Homo sapiens | |
5-chloro-N-(5-chloro-2-pyridyl)-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | - |
Homo sapiens | |
5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | AS1468240, potent inhibitor | Homo sapiens | |
5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | - |
Homo sapiens | |
apixaban | - |
Homo sapiens | |
darexaban | - |
Homo sapiens | |
DPC423 | - |
Homo sapiens | |
edoxaban | - |
Homo sapiens | |
N-(2-chlorophenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 11% inhibition at 0.00136 mM | Homo sapiens | |
N-(3-chloro-4-methoxyphenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 39% inhibition at 0.00136 mM | Homo sapiens | |
N-(3-chlorophenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 76% inhibition at 0.00136 mM | Homo sapiens | |
N-(3-methoxyphenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 40% inhibition at 0.00136 mM | Homo sapiens | |
N-(4-chlorophenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | complete inhibition at 0.00136 mM | Homo sapiens | |
N-(4-ethylphenyl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 15% inhibition at 0.00136 mM | Homo sapiens | |
N-(5-chloro-2-pyridyl)-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | - |
Homo sapiens | |
N-(6-methoxypyridin-3-yl)-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 7% inhibition at 0.00136 mM | Homo sapiens | |
N-[4-(dimethylamino)phenyl]-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | 24% inhibition at 0.00136 mM | Homo sapiens | |
rivaroxaban | - |
Homo sapiens | |
YM-22714 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
trhombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | trhombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000015 | - |
at pH 8.4 and 37°C | Homo sapiens | 5-chloro-3-[(5-chloro-2-pyridyl)carbamoyl]-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]phenyl beta-D-glucopyranosiduronic acid | |
0.0000024 | - |
at pH 8.4 and 37°C | Homo sapiens | DPC423 | |
0.0000036 | - |
at pH 8.4 and 37°C | Homo sapiens | 5-chloro-N-(5-chloro-2-pyridyl)-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | |
0.0000069 | - |
at pH 8.4 and 37°C | Homo sapiens | 4'-chloro-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | |
0.0000087 | - |
at pH 8.4 and 37°C | Homo sapiens | 5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide | |
0.000016 | - |
at pH 8.4 and 37°C | Homo sapiens | N-(5-chloro-2-pyridyl)-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | |
0.000061 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-hydroxy-4'-methoxy-4-methyl-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | |
0.000066 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-[(4-methoxyphenyl)carbamoyl]-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]phenyl beta-D-glucopyranosiduronic acid | |
0.000068 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-hydroxy-4'-methyl-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | |
0.000068 | - |
at pH 8.4 and 37°C | Homo sapiens | 5-chloro-3-hydroxy-4'-methoxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | |
0.00015 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-hydroxy-4'-methoxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzanilide | |
0.00022 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-hydroxy-N-(5-methoxy-2-pyridyl)-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide | |
0.00029 | - |
at pH 8.4 and 37°C | Homo sapiens | 3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]-N-(5-methyl-2-pyridyl)benzamide | |
14 | - |
at pH 8.4 and 37°C | Homo sapiens | 5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxy-2-[[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino]benzamide |