KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics with wild-type and mutant prothrombin substrates, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | cleavage at Arg320 followed by cleavage at Arg271 | thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | cleavage at Arg320 followed by cleavage at Arg271 | Homo sapiens | thrombin + ? | - |
? | |
prothrombin + H2O | cleavage at Arg320 followed by cleavage at Arg271. Enzyme activity and active site docking with wild-type prothrombin and cleavage site variants, in which the cleavage sequence Asp-Gly-Arg is replaced e.g. by Arg-Gly-Arg or Arg-Arg, overview. Product identification, overview | Homo sapiens | thrombin + ? | - |
? | |
S2238 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
prothrombinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
96 | - |
prothrombin | wild-type substrate, for cleavage at Arg320 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Homo sapiens |