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Literature summary for 3.4.21.6 extracted from

  • Borensztajn, K.; Bijlsma, M.F.; Reitsma, P.H.; Peppelenbosch, M.P.; Spek, C.A.
    Coagulation Factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation (2009), Thromb. Res., 124, 219-225.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens treatment with factor Xa markedly diminishes the migration of different cancer cell lines from breast, lung and colon. Factor Xa mediates inhibition of cancer cell migration specifically and dose dependently. It acts via protease-activated receptor-1 dependent signaling. The G protein alpha 1 pathway is not involved in signaling ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information treatment with factor Xa markedly diminishes the migration of different cancer cell lines from breast, lung and colon. Factor Xa mediates inhibition of cancer cell migration specifically and dose dependently. It acts via protease-activated receptor-1 dependent signaling. The G protein alpha 1 pathway is not involved in signaling Homo sapiens ?
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 ?