Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.6 extracted from

  • Wong, P.C.; Crain, E.J.; Xin, B.; Wexler, R.R.; Lam, P.Y.; Pinto, D.J.; Luettgen, J.M.; Knabb, R.M.
    Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies (2008), J. Thromb. Haemost., 6, 820-829.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
apixaban
-
Canis lupus familiaris
apixaban inhibitor does not alter platelet aggregation to ADP, gamma-thrombin, and collagen Homo sapiens
apixaban inhibitor does not alter platelet aggregation to ADP, gamma-thrombin, and collagen. In vivo, apixaban is effective in the prevention of experimental thrombosis at doses that preserve hemostasis Oryctolagus cuniculus
apixaban
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.036
-
L-Arg-Gly-L-Arg-4-nitroanilide 25°C Homo sapiens
0.06
-
L-Arg-Gly-L-Arg-4-nitroanilide 25°C Oryctolagus cuniculus
0.07
-
L-Arg-Gly-L-Arg-4-nitroanilide 25°C Canis lupus familiaris
0.24
-
L-Arg-Gly-L-Arg-4-nitroanilide 25°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg-Gly-L-Arg-4-nitroanilide + H2O
-
Homo sapiens L-Arg-Gly-L-Arg + 4-nitroaniline
-
?
L-Arg-Gly-L-Arg-4-nitroanilide + H2O
-
Rattus norvegicus L-Arg-Gly-L-Arg + 4-nitroaniline
-
?
L-Arg-Gly-L-Arg-4-nitroanilide + H2O
-
Oryctolagus cuniculus L-Arg-Gly-L-Arg + 4-nitroaniline
-
?
L-Arg-Gly-L-Arg-4-nitroanilide + H2O
-
Canis lupus familiaris L-Arg-Gly-L-Arg + 4-nitroaniline
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000016
-
apixaban 25°C Oryctolagus cuniculus
0.00000008
-
apixaban 25°C Homo sapiens
0.00000013
-
apixaban 25°C Rattus norvegicus
0.00000017
-
apixaban 25°C Canis lupus familiaris