Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apixaban | - |
Canis lupus familiaris | |
apixaban | inhibitor does not alter platelet aggregation to ADP, gamma-thrombin, and collagen | Homo sapiens | |
apixaban | inhibitor does not alter platelet aggregation to ADP, gamma-thrombin, and collagen. In vivo, apixaban is effective in the prevention of experimental thrombosis at doses that preserve hemostasis | Oryctolagus cuniculus | |
apixaban | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.036 | - |
L-Arg-Gly-L-Arg-4-nitroanilide | 25°C | Homo sapiens | |
0.06 | - |
L-Arg-Gly-L-Arg-4-nitroanilide | 25°C | Oryctolagus cuniculus | |
0.07 | - |
L-Arg-Gly-L-Arg-4-nitroanilide | 25°C | Canis lupus familiaris | |
0.24 | - |
L-Arg-Gly-L-Arg-4-nitroanilide | 25°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Arg-Gly-L-Arg-4-nitroanilide + H2O | - |
Homo sapiens | L-Arg-Gly-L-Arg + 4-nitroaniline | - |
? | |
L-Arg-Gly-L-Arg-4-nitroanilide + H2O | - |
Rattus norvegicus | L-Arg-Gly-L-Arg + 4-nitroaniline | - |
? | |
L-Arg-Gly-L-Arg-4-nitroanilide + H2O | - |
Oryctolagus cuniculus | L-Arg-Gly-L-Arg + 4-nitroaniline | - |
? | |
L-Arg-Gly-L-Arg-4-nitroanilide + H2O | - |
Canis lupus familiaris | L-Arg-Gly-L-Arg + 4-nitroaniline | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000016 | - |
apixaban | 25°C | Oryctolagus cuniculus | |
0.00000008 | - |
apixaban | 25°C | Homo sapiens | |
0.00000013 | - |
apixaban | 25°C | Rattus norvegicus | |
0.00000017 | - |
apixaban | 25°C | Canis lupus familiaris |