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Literature summary for 3.4.21.6 extracted from

  • Bhattacharjee, G.; Ahamed, J.; Pawlinski, R.; Liu, C.; Mackman, N.; Ruf, W.; Edgington, T.S.
    Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 (2008), Circ. Res., 102, 457-464.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens annexin 2 acts as a receptor for factor Xa on the cell surface. It facilitates factor Xa activation of receptor PAR-1 but does not enhance coagulant function of factor Xa. Overexpression of tissue factor abolishes annexin 2 dependence on factor Xa signaling and diminishes binding to cell surface annexin 2, whereas selectively abolishing tissue factor promotes the annexin 2/factor Xa interaction ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell annexin 2 acts as a receptor for factor Xa on the cell surface. It facilitates factor Xa activation of receptor PAR-1 but does not enhance coagulant function of factor Xa. Overexpression of tissue factor abolishes annexin 2 dependence on factor Xa signaling and diminishes binding to cell surface annexin 2, whereas selectively abolishing tissue factor promotes the annexin 2/factor Xa interaction Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information annexin 2 acts as a receptor for factor Xa on the cell surface. It facilitates factor Xa activation of receptor PAR-1 but does not enhance coagulant function of factor Xa. Overexpression of tissue factor abolishes annexin 2 dependence on factor Xa signaling and diminishes binding to cell surface annexin 2, whereas selectively abolishing tissue factor promotes the annexin 2/factor Xa interaction Homo sapiens ?
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