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Literature summary for 3.4.21.6 extracted from

  • Majumder, R.; Quinn-Allen, M.A.; Kane, W.H.; Lentz, B.R.
    A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex (2008), Blood, 112, 2795-2802.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
1,2-dicaproyl-sn-glycero-3-phospho-L-serine the cofactor activity of factor Va is enhanced in presence of 1,2-dicaproyl-sn-glycero-3-phospho-L-serine. Both C1 and C2 domains of factor Va bind one molecule of 1,2-dicaproyl-sn-glycero-3-phospho-L-serine, with binding to the C1 domain regulating prothrombinase complex assembly Homo sapiens
Factor Va expression of factor Va with mutations in either the C1 domain, Y1956A/L1957A, the C2 domain, W2063A/W2064A, or both C domains, Y1956A/L1957A/W2063A/W2064A. Mutations in the C1 and C1-C2 domains of recombinant factor Va reduce the rate of activation of prothrombin to thrombin by factor Xa in the presence of 1,2-dicaproyl-sn-glycero-3-phospho-L-serine by 14000- to 15000fold relative to either wild-type or C2 mutant factor Va. The Kd values of factor Xa binding with factor Va wild-type, C2 mutant, C1 mutant, and C1-C2 mutant are 3, 4, 564, and 624 nM, respectively Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Homo sapiens
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