Literature summary for 3.4.21.6 extracted from

Joo, S.S.; Won, T.J.; Kim, J.S.; Yoo, Y.M.; Tak, E.S.; Park, S.Y.; Park, H.Y.; Hwang, K.W.; Park, S.C.; Lee, D.I.
Inhibition of coagulation activation and inflammation by a novel Factor Xa inhibitor synthesized from the earthworm Eisenia andrei (2009), Biol. Pharm. Bull., 32, 253-258.

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Inhibitors

Inhibitors	Comment	Organism	Structure
eisenstasin	protein inhibitor isolated from the midgut of Eisenia andrei	Homo sapiens
NH2-RCRFGYR-OH	i.e. ESP, small peptide derived from protein inhibitor eisenstasin. ESP exhibits a high level of factor Xa inhibition in chromogenic peptide substrate assays and inhibits proteinase-activated receptor 2-mediated factor Xa activation resulting in significant reduction of endothelial nitric oxide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVE-12 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzoyl-Ile-Glu(gamma-O-methyl)-Gly-Arg-4-nitroanilide + N-benzoyl-Ile-Glu-Gly-Arg-4-nitroanilide + H2O	mixed substrate S2222	Homo sapiens	benzoyl-Ile-Glu(gamma-O-methyl)-Gly-Arg + N-benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline	-	?

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Release 2023.1 (January 2023)