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Literature summary for 3.4.21.6 extracted from

  • Daubie, V.; Cauwenberghs, S.; Senden, N.H.; Pochet, R.; Lindhout, T.; Buurman, W.A.; Heemskerk, J.W.
    Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation (2006), Biochim. Biophys. Acta, 1763, 860-869.
    View publication on PubMed
Search for more literature for 3.4.21.6

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation of CA2+ responses by tissue factor TF or factor VIIa Homo sapiens
additional information no activation of CA2+ responses by tissue factor TF or factor VIIa Bos taurus
Phospholipids
-
 Homo sapiens
Phospholipids
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
antithrombin complete inhibition Bos taurus
antithrombin complete inhibition Homo sapiens
DEGR-chloromethyl ketone inactivation Bos taurus
DEGR-chloromethyl ketone inactivation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-dependent binding of factor Xa to e.g. phospholipids Homo sapiens
Ca2+ Ca2+-dependent binding of factor Xa to e.g. phospholipids Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview ?
-
 ?
additional information Bos taurus factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview ?
-
 ?
protease-activated receptor 1 + H2O Homo sapiens PAR-1 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 1 + H2O Bos taurus PAR-1 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 2 + H2O Homo sapiens PAR-2 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 2 + ?
-
 ?
protease-activated receptor 2 + H2O Bos taurus PAR-2 activation mediates activation of phospholipase C in endothelial cells activated protease-activated receptor 2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the factor X is activated to factor Xa by Russell's viper venom Homo sapiens
proteolytic modification the factor X is activated to factor Xa by Russell's viper venom Bos taurus

Purification (Commentary)

Purification (Comment) Organism
native factor X from plasma Homo sapiens
native factor X from plasma Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-
plasma
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 measurement of Ca2+ responses, oscillatory response pattern, overview Homo sapiens
additional information
-
 measurement of Ca2+ responses, oscillatory response pattern, overview Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview Homo sapiens ?
-
 ?
additional information factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation, overview Bos taurus ?
-
 ?
protease-activated receptor 1 + H2O
-
 Homo sapiens activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 1 + H2O
-
 Bos taurus activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 1 + H2O PAR-1 activation mediates activation of phospholipase C in endothelial cells Homo sapiens activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 1 + H2O PAR-1 activation mediates activation of phospholipase C in endothelial cells Bos taurus activated protease-activated receptor 1 + ?
-
 ?
protease-activated receptor 2 + H2O
-
 Homo sapiens activated protease-activated receptor 2 + ?
-
 ?
protease-activated receptor 2 + H2O
-
 Bos taurus activated protease-activated receptor 2 + ?
-
 ?
protease-activated receptor 2 + H2O PAR-2 activation mediates activation of phospholipase C in endothelial cells Homo sapiens activated protease-activated receptor 2 + ?
-
 ?
protease-activated receptor 2 + H2O PAR-2 activation mediates activation of phospholipase C in endothelial cells Bos taurus activated protease-activated receptor 2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
factor Xa
-
 Bos taurus