Literature summary for 3.4.21.6 extracted from

Lorentsen, R.H.; Moller, C.H.; Etzerodt, M.; Thogersen, H.C.; Holtet, T.L.
Substrate turnover and inhibitor binding as selection parameters in directed evolution of blood coagulation factor Xa (2003), Org. Biomol. Chem., 1, 1657-1663.

Search for more literature for 3.4.21.6

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of factor Xa-trypsin hybrids, display on phage for selection of a mutant with domain architecture of trypsin and specificity of factor Xa	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Bovine pancreatic trypsin inhibitor	factor Xa-trypsin hybrid mutants	Homo sapiens
Soybean trypsin inhibitor	factor Xa-trypsin hybrid mutants	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin	scutelarin has similar specificity	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
prothrombin + H2O	-	Homo sapiens	thrombin + ?	-	?

Synonyms

Synonyms	Comment	Organism
blood coagulation factor Xa	-	Homo sapiens
More	the enzyme belongs to the peptidase family S1, i.e. trypsin family	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)