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Literature summary for 3.4.21.6 extracted from

  • Li, Y.; Spencer, F.A.; Ball, S.; Becker, R.C.
    Inhibition of platelet-dependent prothrombinase activity and thrombin generation by glycoprotein IIb/IIIa receptor-directed antagonists: potential contributing mechanism of benefit in acute coronary syndromes (2000), J. Thromb. Thrombolysis, 10, 69-76.
    View publication on PubMed
Search for more literature for 3.4.21.6

Application

Application Comment Organism
medicine glycoprotein IIb/IIIa receptor antagonists in combination with heparin might contribute to improved therapy of acute coronary syndromes abd during percutaneous coronary interventions Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
abciximab glycoprotein IIb/IIIa receptor-antagonist, 3.8% inhibition at 0.140 mM in absence of heparin, 49% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens
enoxaparin increases the inhibitory effect of abciximab and eptifibatide Homo sapiens
eptifibatide glycoprotein IIb/IIIa receptor-antagonist, 13.5% inhibition at 0.333 mM in absence of heparin, 38% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens
heparin highly increases the inhibitory effects of glycoprotein IIb/IIIa receptor-antagonists Homo sapiens
tirofiban glycoprotein IIb/IIIa receptor-antagonist, 16.9% inhibition at 0.042 mM in absence of heparin, 48% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-
platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Subunits

Subunits Comment Organism
More factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va Homo sapiens

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens
prothrombinase
-
 Homo sapiens