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Literature summary for 3.4.21.6 extracted from

  • Banerjee, M.; Drummond, D.C.; Srivastava, A.; Daleke, D.; Lentz, B.R.
    Specificity of soluble phospholipid binding sites on human factor Xa (2002), Biochemistry, 41, 7751-7762.
    View publication on PubMed
Search for more literature for 3.4.21.6

Activating Compound

Activating Compound Comment Organism Structure
1,2-dicaproyl-sn-glycero-3-phosphate i.e. C6PA, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phospho-D-homoserine i.e. C6P(homo)S, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phospho-D-serine i.e. C6P(D)S, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phospho-L-N-methylserine i.e. C6P(N-Me)S, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phospho-L-serine i.e. C6PS, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phospho-rac-1-glycerol i.e. C6PG, binding constants in presence of Ca2+ Homo sapiens
1,2-dicaproyl-sn-glycero-3-phosphocholine i.e. C6PC, binding constants in presence of Ca2+ Homo sapiens
1-caproyl-sn-glycero-3-phosphate i.e. C6lysoPA, binding constants in presence of Ca2+ Homo sapiens
1-caproyl-sn-glycero-3-phospho-L-serine i.e. C6lysoPS, binding constants in presence of Ca2+ Homo sapiens
1-caproyl-sn-glycero-3-phosphocholine i.e. C6lysoPC, binding constants in presence of Ca2+ Homo sapiens
L-alpha-glycerophosphorylserine i.e. GPS, binding constants in presence of Ca2+ Homo sapiens
additional information specificity for phosphatidylserine analogues, bound to a pair of linked lipid binding sites involved in regulation of enzyme activity, binding structure and specificity of the 2 binding sites, cooperative and competitive binding Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, part of prothrombinase complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is regulated by sequential occupancy of a pair of linked lipid binding sites, each of which have different minimum ligand structural requirements to induce structural changes ?
-
 ?
prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 enzyme modified with [5-(dimethylamino)-1-naphthalenesulfonyl]glutamylglycylarginyl chloromethyl ketone
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is regulated by sequential occupancy of a pair of linked lipid binding sites, each of which have different minimum ligand structural requirements to induce structural changes Homo sapiens ?
-
 ?
N-alpha-benzyloxycarbonyl-D-arginyl-glycyl-L-arginine-4-nitroanilide + H2O i.e. S-2765, synthetic fluorogenic substrate Homo sapiens N-alpha-benzyloxycarbonyl-D-arginyl-glycyl-L-arginine + 4-nitroaniline
-
 ?
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens