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Literature summary for 3.4.21.6 extracted from

  • Kalafatis, M.; Beck, D.O.
    Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323-331 of factor V represent an interactive site for activated factor X (2002), Biochemistry, 41, 12715-12728.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AP'4 nonapeptide comprising amino acids 323-331 of factor Va, strong, inhibition of prothrombinase activity, noncompetitive with respect to prothrombin, inhibition mechanism Homo sapiens
additional information inhibition potential of overlapping peptides within the region of amino acids 307-348 of factor Va heavy chain Homo sapiens
N24R peptide comprising amino acids 307-348 of the factor Va heavy chain, binds to membrane-bound factor Xa and inhibits its activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
Homo sapiens thrombin + ?
-
?

Subunits

Subunits Comment Organism
More factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va Homo sapiens

Synonyms

Synonyms Comment Organism
factor Xa
-
Homo sapiens
hXa
-
Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Factor Va binding site for factor Xa is located at amino acid residues 307-348 of the heavy chain, purified factor Va is not stable during rapid freezing and thawing Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0057
-
AP'4 pH 7.4 Homo sapiens