Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AP'4 | nonapeptide comprising amino acids 323-331 of factor Va, strong, inhibition of prothrombinase activity, noncompetitive with respect to prothrombin, inhibition mechanism | Homo sapiens | |
additional information | inhibition potential of overlapping peptides within the region of amino acids 307-348 of factor Va heavy chain | Homo sapiens | |
N24R | peptide comprising amino acids 307-348 of the factor Va heavy chain, binds to membrane-bound factor Xa and inhibits its activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
hXa | - |
Homo sapiens |
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Factor Va | binding site for factor Xa is located at amino acid residues 307-348 of the heavy chain, purified factor Va is not stable during rapid freezing and thawing | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0057 | - |
AP'4 | pH 7.4 | Homo sapiens |