Literature summary for 3.4.21.59 extracted from

Schiemann, F.; Brandt, E.; Gross, R.; Lindner, B.; Mittelstaedt, J.; Sommerhoff, C.P.; Schulmistrat, J.; Petersen, F.
The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4 (2009), J. Immunol., 183, 2223-2231.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Pichia pastoris	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	CXCL4 does not act as a direct beta-tryptase inhibitor, but destabilizes active tetrameric enzyme by antagonizing the heparin component required for the integrity of the tetramer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzoyl-L-Phe-L-Val-L-Arg-4-nitroanilide + H2O	-	Homo sapiens	benzoyl-L-Phe-L-Val-L-Arg + 4-nitroaniline	-	?
LL-37 + H2O	the platelet-derived chemokine CXCL4 protects LL-37 from cleavage by beta-tryptase	Homo sapiens	LL-37 fragments	-	?
tosyl-Gly-L-Pro-L-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	tosyl-Gly-L-Pro-L-Arg + 7-amino-4-methylcoumarin	-	?

Subunits

Subunits	Comment	Organism
tetramer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
beta-tryptase	-	Homo sapiens
Mast cell tryptase	-	Homo sapiens

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Release 2023.1 (January 2023)