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Literature summary for 3.4.21.59 extracted from
- Mast cell tryptases and chymases in inflammation and host defense (2007), Immunol. Rev., 217, 141-154.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | beta-tryptases are the major focus of drug development for therapeutic inhibition | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| genetic localization | Mus musculus |
| genetic localization | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MOL 6131 | developed against mast cell beta-tryptase and studied in ovalbumin-induced allergic airway inflammation | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | anchored, gamma-tryptase, i.e. transmembrane tryptase | Mus musculus | 16020 | - |
| membrane | anchored, gamma-tryptase, i.e. transmembrane tryptase | Homo sapiens | 16020 | - |
| soluble | alpha-, beta-, and delta-tryptase | Mus musculus | - |
- |
| soluble | alpha-, beta-, and delta-tryptase | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in allergic inflammation, mechanism, overview | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is involved in allergic inflammation, mechanism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
several enzyme forms | - |
| Mus musculus | - |
C57BL/6 mice, several enzyme forms | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| basophil | beta-tryptase | Mus musculus | - |
| basophil | beta-tryptase | Homo sapiens | - |
| lung | - |
Mus musculus | - |
| lung | - |
Homo sapiens | - |
| mast cell | - |
Mus musculus | - |
| mast cell | - |
Homo sapiens | - |
| respiratory system | - |
Mus musculus | - |
| respiratory system | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in allergic inflammation, mechanism, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme is involved in allergic inflammation, mechanism, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | structure of enzyme forms, overview | Mus musculus |
| tetramer | structure of enzyme forms, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-tryptase | - |
Mus musculus |
| alpha-tryptase | - |
Homo sapiens |
| beta-tryptase | - |
Mus musculus |
| beta-tryptase | - |
Homo sapiens |
| delta-tryptase | - |
Mus musculus |
| delta-tryptase | - |
Homo sapiens |
| gamma-tryptase | - |
Mus musculus |
| gamma-tryptase | - |
Homo sapiens |
| Mast cell tryptase | - |
Mus musculus |
| Mast cell tryptase | - |
Homo sapiens |
| transmembrane tryptase | - |
Mus musculus |
| transmembrane tryptase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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