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Literature summary for 3.4.21.59 extracted from

  • Rest, R.F.
    Human neutrophil and mast cell proteases implicated in inflammation (1988), Methods Enzymol., 163, 309-327.
    View publication on PubMed
Search for more literature for 3.4.21.59

Inhibitors

Inhibitors Comment Organism Structure
antipain
-
 Homo sapiens
benzamidine
-
 Homo sapiens
diisopropyl fluorophosphate
-
 Homo sapiens
leupeptin
-
 Homo sapiens
additional information alpha2-macroglobulin; not: alpha1-proteinase inhibitor Homo sapiens
N-tosyl-L-Lys chloromethyl ketone
-
 Homo sapiens
Trypstatin purification Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
 x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides Homo sapiens
33000
-
 x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides Homo sapiens
135000 144000 human Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-
mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme inactivates fibrinogen and high-molecular weight kininogen and converts C3 to C3a Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
tetramer x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides Homo sapiens