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Literature summary for 3.4.21.53 extracted from

  • Cui, X.; Wei, Y.; Xie, X.L.; Chen, L.N.; Zhang, S.H.
    Mitochondrial and peroxisomal Lon proteases play opposing roles in reproduction and growth but co-function in the normal development, stress resistance and longevity of Thermomyces lanuginosus (2017), Fungal Genet. Biol., 103, 42-54 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence analysis, expression analysis Thermomyces lanuginosus

Protein Variants

Protein Variants Comment Organism
additional information generation of a single-deletion Lon mutant by gene replacement, DELTAMLon showing decreased production of conidia but increased growth of mycelia Thermomyces lanuginosus
additional information generation of a single-deletion Lon mutant by gene replacement, DELTAPLon showing increased production of conidia but decreased growth of mycelia Thermomyces lanuginosus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Thermomyces lanuginosus 5739
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peroxisome
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Thermomyces lanuginosus 5777
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Organism

Organism UniProt Comment Textmining
Thermomyces lanuginosus
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i.e. Humicola lanuginosa
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Thermomyces lanuginosus 9W
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i.e. Humicola lanuginosa
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Source Tissue

Source Tissue Comment Organism Textmining
mycelium growth temperature is 60°C, highest enzyme expression occurs at 35°C in the range of 35-60°C Thermomyces lanuginosus
-

Synonyms

Synonyms Comment Organism
mitochondrial Lon protease
-
Thermomyces lanuginosus
MLon
-
Thermomyces lanuginosus
peroxisomal Lon protease
-
Thermomyces lanuginosus
PLon
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Thermomyces lanuginosus
Thela2p4_005149 locus name Thermomyces lanuginosus
Thela2p4_006664 locus name Thermomyces lanuginosus

General Information

General Information Comment Organism
malfunction the wild-type strain shows continuous linear growth for 60 days, whereas growth is impeded at 30 and 50 days for mitochondrial and peroxisomal isozyme-deficient mutants DELTAPLon and DELTAMLon mutants, respectively, suggesting that PLon is more important for longevity than MLon. Conidia production dramatically increases with the PLon deletion strain but not with the MLon deletion strain. Mutant DELTAPLon strains are more sensitive to multiple stressors than DELTAMLon Thermomyces lanuginosus