Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
gene lon | - |
Synonyms | Comment | Organism |
---|---|---|
lon protease | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
malfunction | lon mutants are supersusceptible to ciprofloxacin, and exhibit a defect in cell division and in virulence-related properties, such as swarming, twitching and biofilm formation, despite the fact that the Lon protease is not a traditional regulator. The lon mutant has a defect in cytotoxicity towards epithelial cells, is less virulent in an amoeba model as well as a mouse acute lung infection model, and is impacted on in vivo survival in a rat model of chronic infection. The lon mutation leads to a downregulation of Type III secretion genes. The Lon protease also influenced motility and biofilm formation in a mucin-rich environment, defective virulence in vivo. Phenotype detailed overview | Pseudomonas aeruginosa |
physiological function | the Lon protease is essential for full virulence in Pseudomonas aeruginosa. The Lon protease is not a traditional regulator | Pseudomonas aeruginosa |