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Literature summary for 3.4.21.53 extracted from

  • Matsushima, Y.; Goto, Y.; Kaguni, L.S.
    Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM) (2010), Proc. Natl. Acad. Sci. USA, 107, 18410-18415.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Schneider cell Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Drosophila melanogaster 5739
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-

General Information

General Information Comment Organism
physiological function reduction of Lon to less than 10% of its normal level in Drosophila Schneider cells by RNAi knockdown results in increased abundance of mitochondrial transcription factor A, TFAM, and mitochondrial DNA copy number. In a corollary manner, overexpression of Lon reduces TFAM levels and mt DNA copy number. Induction of mitochondrial DNA depletion in Lon knockdown cells does not result in degradation of TFAM, thereby causing a dramatic increase in the TFAM:mitochondrial DNA ratio. The increased TFAM:mitochondrial DNA ratio in turn causes inhibition of mitochondrial transcription Drosophila melanogaster