Cloned (Comment) | Organism |
---|---|
- |
Pseudomonas aeruginosa |
gene lon, expression analysis in wild-type and mutant strains by quantitative, real-time reverse transcription PCR, overview | Pseudomonas aeruginosa |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of quorum-sensing signaling system mutant strains, gene lon disrupted cells of mutant strain, CS9008 overproduce pyocyanin, the biosynthesis of which depends on the RhlR/RhlI system, and show increased levels of a transcriptional regulator RhlR, phenotype, overview | Pseudomonas aeruginosa |
additional information | cells with Lon protease gene disruption overproduce pyocyanin and show increased levels of transcriptional regulator RhlR and increased expression of LasR/LasI. Regulation of RhlR/RhlI by Lon is independent of LasR/LasI | Pseudomonas aeruginosa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
89000 | - |
x * 89000, Lon, SDS-PAGE | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
LasI + H2O | Pseudomonas aeruginosa | Lon is involved in the regulation of quorum-sensing signaling systems in Pseudomonas aeruginosa, the opportunistic human pathogen. The enzyme is part of the acyl-homoserine lactone-mediated QS system LasR/LasI, but LasR/LasI regulation is independent of the RhlR/RhlI system by Lon. QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI, Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system, overview | ? | - |
? | |
additional information | Pseudomonas aeruginosa | protease Lon represses the expression of LasR/LasI by degrading HSL synthase LasI, leading to negative regulation of the RhlR/RhlI system. RhlI/RhlR is also regulated by Lon independently of LasI/LasR | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa | Q9I2T9 | gene lon | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
LasI + H2O | Lon is involved in the regulation of quorum-sensing signaling systems in Pseudomonas aeruginosa, the opportunistic human pathogen. The enzyme is part of the acyl-homoserine lactone-mediated QS system LasR/LasI, but LasR/LasI regulation is independent of the RhlR/RhlI system by Lon. QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI, Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system, overview | Pseudomonas aeruginosa | ? | - |
? | |
LasI + H2O | hydrolytic degradation | Pseudomonas aeruginosa | ? | - |
? | |
additional information | protease Lon represses the expression of LasR/LasI by degrading HSL synthase LasI, leading to negative regulation of the RhlR/RhlI system. RhlI/RhlR is also regulated by Lon independently of LasI/LasR | Pseudomonas aeruginosa | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 89000, Lon, SDS-PAGE | Pseudomonas aeruginosa |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent lon protease | - |
Pseudomonas aeruginosa |
lon | - |
Pseudomonas aeruginosa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Pseudomonas aeruginosa |