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Literature summary for 3.4.21.53 extracted from

  • Granot, Z.; Kobiler, O.; Melamed-Book, N.; Eimerl, S.; Bahat, A.; Lu, B.; Braun, S.; Maurizi, M.R.; Suzuki, C.K.; Oppenheim, A.B.; Orly, J.
    Turnover of mitochondrial steroidogenic acute regulatory (StAR) protein by Lon protease: the unexpected effect of proteasome inhibitors (2007), Mol. Endocrinol., 21, 2164-2177.
    View publication on PubMed

Application

Application Comment Organism
additional information lon may be an important defense mechanism to protect mitochondria of steroidogenic cells against oxidative damage induced by steroid hydroxylation and to maintain the level of postfunctional steroidogenic acute regulatory protein compatible with mitochondrial homeostasis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into the NdeI and BamHI sites of proEX, lon (proEX-Lon-His) expressed in Escherichia coli. Plasmid lon O/Ex expressed in COS cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information lon- mutant, steroidogenic acute regulatory protein turnover is blocked Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
clasto-lactacystin beta-lactone blocks lon-mediated degradation of steroidogenic acute regulatory protein or FITC casein Homo sapiens
MG132 blocks lon-mediated degradation of steroidogenic acute regulatory protein or FITC casein Homo sapiens
additional information not inhibited by epoxomicin Homo sapiens
RNAi knockdown of lon Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
on Ni2+-NTA column Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information steroidogenic cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FITC casein + H2O
-
Homo sapiens ?
-
?
steroidogenic acute regulatory protein + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
lon protease
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
-
Homo sapiens clasto-lactacystin beta-lactone
0.02
-
-
Homo sapiens MG132