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Literature summary for 3.4.21.53 extracted from
- The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility (2007), Microbiology, 153, 474-482.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| gentamicin | induces lon protease by subinhibitory concentrations | Pseudomonas aeruginosa |  |
| tobramycin | induces lon protease by subinhibitory concentrations | Pseudomonas aeruginosa | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | subinhibitory concentrations of antibiotics induce a set of genes, e.g. lon protease, that are likely to affect the interaction of Pseudomonas aeruginosa with host cells. lon protease is essential for biofilm formation and motility in Pseudomonas aeruginosa | Pseudomonas aeruginosa |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ORF of the lon gene PA1803 PCR-amplified and cloned into vector TopoBlunt. HindIII-XbaI fragment containing the lon gene ligated into vector pBBR1-MCS5, transformed into Escherichia coli XL-1 Blue and subsequently into Escherichia coli S17-1 for mobilization into Pseudomonas aeruginosa 74-D9 through conjugation | Pseudomonas aeruginosa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | lon mutants show impaired motility compared to the wild-type and a defect in biofilm formation | Pseudomonas aeruginosa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon protease | - |
Pseudomonas aeruginosa |
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