Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of lon increases over time when bacteria are grown in subinhibitory ciprofloxacin concentrations. Subinhibitory antibiotic environments contribute to the development of resistance | Pseudomonas aeruginosa |
Application | Comment | Organism |
---|---|---|
medicine | potential therapeutic antimicrobial target to combat fluoroquinolone resistance | Pseudomonas aeruginosa |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutants in PA1803, a close homolog of the ATP-dependent lon protease, exhibit more than 4fold-increased susceptibilities to ciprofloxacin and 2fold more susceptibilities to norfloxacin and nalidixic acid, but not to gentamicin or imipenem, as well as a characteristic elongated morphology. Complementation of the lon mutant restores wild-type antibiotic susceptibility and cell morphology | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
PAO1 strain H103 | - |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Pseudomonas aeruginosa |
lon protease | - |
Pseudomonas aeruginosa |