Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no activation by ubiquitin | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Escherichia coli | |
Mg2+ | required for maximal ATP-binding and essential for proteolytic activity | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
87000 | - |
4 * 87000, | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Proteins with highly abnormal conformation + H2O | Escherichia coli | catalyzes inital step in the degradation of proteins with abnormal conformation as may result from nonsense or missense mutations, biosynthetic errors or intracellular denaturation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
hydrolysis of proteins in presence of ATP | hydrolysis of proteins in presence of ATP, mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fluorogenic peptides + H2O | - |
Escherichia coli | ? | - |
? | |
Proteins with highly abnormal conformation + H2O | catalyzes inital step in the degradation of proteins with abnormal conformation as may result from nonsense or missense mutations, biosynthetic errors or intracellular denaturation | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 87000, | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | requirement | Escherichia coli | |
ATP | enzyme tetramer has two high and two low affinity binding sites for ATP | Escherichia coli | |
ATP | two ATP molecules are hydrolyzed for each peptide bond cleaved in proteins | Escherichia coli | |
ATP | only phosphate is released after ATP hydrolysis | Escherichia coli | |
ATP | ATP-dependent protease | Escherichia coli |