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Literature summary for 3.4.21.50 extracted from

  • Marquart, M.E.; Dajcs, J.J.; Caballero, A.R.; Thibodeaux, B.A.; OCallaghan, R.J.
    Calcium and magnesium enhance the production of Pseudomonas aeruginosa protease IV , a corneal virulence factor (2005), Med. Microbiol. Immunol., 194, 39-45.
    View publication on PubMed
Search for more literature for 3.4.21.50

Application

Application Comment Organism
medicine following infection with Pseudomonas aeruginosa, Ca2+ increase in the cornea can favor production of enzyme, which has been associated with corneal damage Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
tosyl-L-lysine chloromethylketone i.e. TLCK Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ enhances the enzyme production in strain PA103 Pseudomonas aeruginosa
Mg2+ enhances the enzyme production in strain PA103 Pseudomonas aeruginosa
additional information no effects by Cl- Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa the enzyme is a corneal virulence factor of Pseudomonas aeruginosa ?
-
 ?
additional information Pseudomonas aeruginosa PA103 the enzyme is a corneal virulence factor of Pseudomonas aeruginosa ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa
-
 enzyme activity increases upon growth in media supplemented with Ca2+ or Mg2+
-
Pseudomonas aeruginosa PA103
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
casein + H2O
-
 Pseudomonas aeruginosa PA103 ?
-
 ?
additional information the enzyme is a corneal virulence factor of Pseudomonas aeruginosa Pseudomonas aeruginosa ?
-
 ?
additional information the enzyme is a corneal virulence factor of Pseudomonas aeruginosa Pseudomonas aeruginosa PA103 ?
-
 ?
tosyl-Gly-Pro-Lys-4-nitroanilide + H2O a chromogenic substrate Pseudomonas aeruginosa tosyl-Gly-Pro-Lys + 4-nitroaniline
-
 ?
tosyl-Gly-Pro-Lys-4-nitroanilide + H2O a chromogenic substrate Pseudomonas aeruginosa PA103 tosyl-Gly-Pro-Lys + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
caseinase
-
 Pseudomonas aeruginosa
lysine endoproteinase
-
 Pseudomonas aeruginosa
protease IV
-
 Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Pseudomonas aeruginosa