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Literature summary for 3.4.21.5 extracted from

  • Chahal, G.; Thorpe, M.; Hellman, L.
    The importance of exosite interactions for substrate cleavage by human thrombin (2015), PLoS ONE, 10, e0129511 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P00734 prothrombin
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coagulation factor V + H2O
-
Homo sapiens ?
-
?
coagulation factor VIII + H2O
-
Homo sapiens ?
-
?
additional information electropositive regions at a distance from the active site, so called exosites, are of major importance for the cleavage by human thrombin. Addition of these regions enhance the cleavage rate by more than fifty fold. The enhancement is highly dependent on the sequence of the actual cleavage site. A minimal site that shows poor activity by itself can be cleaved as efficiently as an optimal cleavage site when presented together with these negatively charged regions. Sites conforming closely to the optimal site are only minimally enhanced by the addition of these regions Homo sapiens ?
-
?
protein C
-
Homo sapiens ?
-
?