Literature summary for 3.4.21.5 extracted from

Grade, S.; Agasse, F.; Bernardino, L.; Silva, C.G.; Cortes, L.; Malva, J.O.
Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin (2010), Rejuvenation Res., 13, 27-37.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	O4+ and proteolipid protein-positive oligodendrocytes display a robust intracellular calcium level rise following thrombin stimulation. Thrombin-induced Ca2+ increase in oligodendrocytes is mediated by protease-activated receptor-1 activation and downstream signaling through G(q/11) and phospholipase C, resulting in Ca2+ recruitment from intracellular compartments	Homo sapiens

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Release 2023.1 (January 2023)