Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-Phe-Pro-Arg-chloromethylketone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
alpha-thrombin | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | thrombin induces the expression of oncostatin M via AP-1 activation in human monocyte-derived macrophages, peripheral blood monocytes, and human plaque macrophages up to 16.8fold after 24 h. Thrombin induces phosphorylation of ERK1/2 and p38 in monocyte-derived macrophages. A functional AP-1 site is required for oncostatin M promoter activation by thrombin | Homo sapiens |