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Literature summary for 3.4.21.5 extracted from

  • Yin, X.; Wright, J.; Wall, T.; Grammas, P.
    Brain endothelial cells synthesize neurotoxic thrombin in Alzheimers disease (2010), Am. J. Pathol., 176, 1600-1606.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel wall sections from Alzheimer's disease brains show reactivity to thrombin antibody in blood vessel walls but not in vessels from controls Homo sapiens
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brain endothelium
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Rattus norvegicus
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brain endothelium brain endothelial cells can synthesize thrombin and thus be a source of this neurotoxin in Alzheimer's disease brains Homo sapiens
-
cerebrospinal fluid high levels of thrombin are detected in cerebrospinal fluid obtained from Alzheimer's disease but not control patients Homo sapiens
-
microvessel thrombin is highly expressed in microvessels from Alzheimer's disease brains but is not detectable in control vessels Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells up
Rattus norvegicus oxidative stress or cell signaling perturbations lead to increased expression of thrombin mRNA in brain endothelial cells up