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Literature summary for 3.4.21.5 extracted from

  • De Smedt, E.; Wagenvoord, R.; Coen Hemker, H.
    The technique of measuring thrombin generation with fluorogenic substrates: 3. The effects of sample dilution (2009), Thromb. Haemost., 101, 165-170.
    View publication on PubMed

Application

Application Comment Organism
analysis study on the effects of dilution on the thrombin generation process in assessing the clotting function. Anticoagulant pathways are far more affected by dilution than the procoagulant pathways. Plasma dilution causes a loss of sensitivity towards thrombomodulin and activated protein C. At dilutions above 1:12 a second wave of prothrombinase-activity is observed Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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