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Literature summary for 3.4.21.5 extracted from

  • Erez, O.; Romero, R.; Kim, S.S.; Kim, J.S.; Kim, Y.M.; Wildman, D.E.; Than, N.G.; Mazaki-Tovi, S.; Gotsch, F.; Pineles, B.; Kusanovic, J.P.; Espinoza, J.; Mittal, P.; Mazor, M.; Hassan, S.S.; Kim, C.J.
    Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation (2008), J. Matern. Fetal. Neonatal. Med., 21, 345-355.
    View publication on PubMedView publication on EuropePMC
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Application Comment Organism
medicine placentas from pregnancies complicated by preterm preeclampsia have a significantly higher frequency of strong receptor PAR-1 expression than placentas from women with spontaneous pre-term labour. Role for PAR-1 as a mediator of the effect of thrombin on coagulation and inflammation in preeclampsia. The effects of thrombin in preeclampsia are due to increased thrombin generation and higher expression of PAR-1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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