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Literature summary for 3.4.21.5 extracted from
- Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin (2009), Clin. Chim. Acta, 401, 119-123.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in patients with rheumatoid arthritis, citrullinated fibrin and fibrinogen are present in the synovium. Citrullinated fibrinogen is not a substrate for thrombin and may be associated with the pathophysiology of rheumatoid arthritis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
gamma-thrombin, commercial preparation | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | citrullinated fibrinogen is no substrate. Thrombin does not catalyze the conversion of citrullinated fibrinogen to fibrin or relase fibrinopeptide A or fibrinopeptide B | Homo sapiens | ? | - |
? |  |
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