Application | Comment | Organism |
---|---|---|
medicine | beta2-glycoprotein I may regulate thrombin inactivation by heparin cofactor II. The presence of anti-beta2-glycoprotein I antibodies potentiates the protective effect of beta2-glycoprotein I on thrombin and may explain the prothrombic tendency in patients with antiphospholipid syndrome | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin cofactor II | presence of beta2-glycoprotein I protects thrombin against inactivation by heparin cofactor II. Cleavage of beta2-glycoprotein I at residues K317-T318 abrogates its protective effect | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
commercial product | - |