Activating Compound | Comment | Organism | Structure |
---|---|---|---|
protease-activated receptor 3 | the cleaved form of protease-activated receptor 3, PAR-3, acts as a cofactor for thrombin cleavage and activation of PAR-4 on murine platelets, interaction analysis of thrombin with the extracellular part of PAR-3, overview | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
wild-type and mutant S195A thrombins in complex with the extracellular fragments of murine protease-activated receptors PAR-3 and PAR-4, X-ray diffraction structure determination and anaylsis at 2.0-3.5 A resolution | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S195A | mutation of the catalytic residue, inactive mutant | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Mus musculus | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | cell surface | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protease-activated receptor 4 + H2O | the cleaved form of protease-activated receptor 3, PAR-3, acts as a cofactor for thrombin cleavage and activation of PAR-4 on murine platelets, interaction analysis of thrombin with the extracellular part of PAR-4, overview | Mus musculus | activated PAR-4 + ? | - |
? |