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Literature summary for 3.4.21.5 extracted from

  • Bah, A.; Chen, Z.; Bush-Pelc, L.A.; Mathews, F.S.; Di Cera, E.
    Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4 (2007), Proc. Natl. Acad. Sci. USA, 104, 11603-11608.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
protease-activated receptor 3 the cleaved form of protease-activated receptor 3, PAR-3, acts as a cofactor for thrombin cleavage and activation of PAR-4 on murine platelets, interaction analysis of thrombin with the extracellular part of PAR-3, overview Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type and mutant S195A thrombins in complex with the extracellular fragments of murine protease-activated receptors PAR-3 and PAR-4, X-ray diffraction structure determination and anaylsis at 2.0-3.5 A resolution Mus musculus

Protein Variants

Protein Variants Comment Organism
S195A mutation of the catalytic residue, inactive mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Mus musculus 9986
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet cell surface Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protease-activated receptor 4 + H2O the cleaved form of protease-activated receptor 3, PAR-3, acts as a cofactor for thrombin cleavage and activation of PAR-4 on murine platelets, interaction analysis of thrombin with the extracellular part of PAR-4, overview Mus musculus activated PAR-4 + ?
-
?