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Literature summary for 3.4.21.5 extracted from

  • Pineda, A.O.; Chen, Z.W.; Marino, F.; Mathews, F.S.; Mosesson, M.W.; Di Cera, E.
    Crystal structure of thrombin in complex with fibrinogen gamma peptide (2007), Biophys. Chem., 125, 556-559.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
gamma' peptide extensive interactions between thrombin and the gamma' peptide mediated by electrostatic contacts with residues of exosite II and hydrophobic interactions with a pocket in close proximity to the Na+ binding site, complex structure and binding mode, the gamma' peptide completely overlaps with heparin bound to exosite II, overview Homo sapiens
heparin extensive interactions between thrombin and the gamma' peptide mediated by electrostatic contacts with residues of exosite II and hydrophobic interactions with a pocket in close proximity to the Na+ binding site, complex structure and binding mode, the gamma' peptide completely overlaps with heparin bound to exosite II, overview Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
thrombin in complex with fibrinogen gamma' peptide, X-ray diffraction structure determination and analysis at 2.4 A resolution Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ binding site structure, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + ?
-
?
fibrinogen + H2O activation, mechanism, overview Homo sapiens fibrin + ?
-
?
additional information extensive interactions between thrombin and the gamma' peptide mediated by electrostatic contacts with residues of exosite II and hydrophobic interactions with a pocket in close proximity to the Na+ binding site, complex structure and binding mode, the gamma' peptide completely overlaps with heparin bound to exosite II, overview Homo sapiens ?
-
?