Application | Comment | Organism |
---|---|---|
medicine | mechanism of high affinity fibrinogen binding and cleavage in Staphylococcus aureus mediated endocarditis | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
prethrombin 2 bound to a fully active fragment of residues 1-325 from Staphylococcus aureus staphylocoagluase. Complex forms dimers | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | Staphylococcus aureus staphylocoagluase activates proenzyme without proteolysis. Staphylocoagulase-enzyme complex forms a dimer that binds substrate fibrinogen with dissociation constant of 8-34 nM | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | Staphylococcus aureus staphylocoagluase activates proenzyme without proteolysis. Staphylocoagulase-enzyme complex forms a dimer that binds fibrinogen with dissociation constant of 8-34 nM | Homo sapiens |