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Literature summary for 3.4.21.5 extracted from
- Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site (2005), Blood, 105, 4362-4368.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme activation of factor VIII mutant R372H, occuring in patients with hemophilia A, is about 80fold decreased, resulting in generation of about 6.1 nM factor X4 per min compared to 13 nM for wild-type | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
comercial preparation | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor VIII + H2O | - |
Homo sapiens | ? | - |
? |  |
| factor VIII mutant R372H + H2O | naturally occuring mutation in hemophilia A patients. About 80fold decrease in cleavage rate compared to wild-type substrate, cleavage at H372-S373 bond | Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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